Growing Your Own Replacement Parts

 

This is simply incredible. Watch the video about Claudia Castillo growing a replacement to part of her windpipe with her own stem cells. She didn’t grow the complete tube, but nevertheless…

Ms Castillo, who was born in Colombia, had suffered a tuberculosis infection that ravaged her airways, leaving her unable to do simple domestic tasks. Disease had caused her windpipe, or trachea, to collapse just at the point where it entered her lung. Without the pioneering operation in June, the lung would have been removed. Today she again has a normal life and is able to look after her two children. She can walk up stairs without getting breathless and has even been dancing.

Oh, my. Can you believe this? What the future holds for all the folks with damaged parts…

And does this mean as we age, we’ll be able to swap out the old for new? How will that affect aging? This is simply incredible.

Share

Similar Posts

  • |

    Camille Paglia, Word Ninja

    I think I must disagree with half of everything Paglia says (I’m a Republican, she’s a Democrat). But when you can write like a kung fu master, you have to be read:

    Advanced whack-a-mole is clearly needed for that yammering smarty-pants Newt Gingrich, who is always so very, very pleased with himself but has yet to produce a single enduring thought.

    Holy schnitzel, that’s what words are for. I’m still laughing and nodding my head. Can I be Camille for a while?

    The fact is while Paglia is clearly liberal, she’s not a party lemming. This is one of the things that is so refreshing about her. She’s not afraid to call ’em as she sees them, even if that means roasting her own party or praising the other.

    More here: Too late for Obama to turn it around? Plus: The left’s visionaries lost their bearings on drugs — but the GOP is led by losers

    And here: Paglia page.

    Share
  • |

    Buffett’s Letter to Berkshire Hathaway Shareholders on 2008

    I got my masters degree in accounting and information systems. While going to school I started an investment club and learned about a man named Warren Buffett.

    Warren Buffett is humble, full of folksy humor, and trades places with Bill Gates as the richest man in the world, depending on the year you’re counting. His annual letters to his shareholders are a delight to read. This year’s is full of wisdom about the current financial crisis. Moreover, within a few minutes of reading you will be able to get some key insights that can help as you evaluate the plans being hatched in Washington and how to prevent this particular type of crisis from happening again. 

    If you’re not that into finance, I recommend reading:

     

    1. The introduction starting on page 2 and ending on page 3
    2. The “Finance and Financial Products” section starting on page 10 and running through page 12

    Once you’ve read those, if you want to laugh and see Buffet’s humor, skip to page 21 where Buffett talks about the annual meeting of shareholders. Tell me you wouldn’t want to attend.

    The Berkshire Hathaway homepage

    This year’s letter to shareholders (you will click on 2008 because he’s discussing the results of that year)

    Share
  • Intelligence and Genetics

    Albert Einstein, an Ashkenazim Jew
    Albert Einstein, an Ashkenazim Jew

    I know that discussing genetic factors of intelligence is something many do not want to do because such notions have been used horribly in the past. And because there are groups who would like to continue such horrible abuses today.

    However, it makes no sense to me to avoid such discussions. There are so many things, from mental illness to physical strength, that have genetic factors that it’s just stupid to ignore data that suggest intelligence also has such factors.

    And so I offer you this paper from three folks at the University of Utah which “elaborates the hypothesis that the unique demography and sociology of Ashkenazim in medieval Europe [Jews descended from the medieval Jewish communities of the Rhineland in the west of Germany] selected for intelligence.”

    It may turn out the hypothesis of these researchers is wrong. But you’ll never know even what they’re proposing without giving it a gander.

    http://homepage.mac.com/harpend/.Public/AshkenaziIQ.jbiosocsci.pdf

    Share
  • Health Care Solutions

    I am a big believer in free-market solutions. However, I’m not a big believer in Wild West capitalism. Government plays a vital role in helping us prevent capitalistic abuse. But what’s the right role of government in health care?

    I found that both John Stossel’s 20/20 “Sick in America” and a recent report from Safeway give brilliant insight into the situation and possible solutions. Enjoy!

    Sick in America Part 2
    Sick in America Part 3
    Sick in America Part 4
    Sick in America Part 5
    Sick in America Part 6

    How Safeway Is Cutting Health-Care Costs from the Wall Street Journal

    Share
  • AIG bailout, risk, and writing

    With the current financial “crisis” I kept wondering what went wrong. Read this article on the AIG mess from the guys at the Motley Fool. That explaination of the AIG mess is very interesting. The other part of this current financial mess, the loaning-of-money-to-people-who-were-idiotic-credit-risks and the making-me-foot-the-bill-for-someone-else’s-assumption-of-ridiculous-risk, those two parts torque me.

    So why am I posting this in the Zing and Writers categories?

    Because it IS zing to me. You could write a high-finance thriller about this. You could write about a character who leveraged himself silly and is about to lose it all–in a smaller sense. You could write, hey, wait a minute. I just read a book about something similar–THE CHAIRMAN by Stephen Frey. It’s a 2.5/5 star book. Good enough that I had to finish it. Although not good enough to make my recommendation list. 

    The point is that stories are about problems and conflicts. And this understanding of the insurance industry provides some fertile ideas for both problems and conflicts.

    And since I can’t get the blasted link to work, here’s the full deal.

    AIG’s Failure Is So Much Bigger Than Enron
    By Andrew Sullivan, CFA
    September 17, 2008 Comment (54) Recommend (124)
    Enron — reviled, fraudulent Enron — destroyed more than $60 billion of shareholder value.

    AIG (NYSE: AIG), which the government just took over, has destroyed $180 billion already — and it almost brought down our entire financial system.

    We don’t know money
    Which is ironic, given AIG’s old television commercials, in which the giant letters “A I G” displayed on the screen while text flashed underneath that culminated in the following phrase — all in capital letters:

    WE KNOW MONEY

    There were no smiling couples, young children at play, or lounging retirees. No, AIG was above that — it was better than that.

    But here’s a news flash, AIG: You don’t know money.

    If you did, you’d have realized a few things. Insurance is terribly simple, as long as you follow the Three Rules:

    Price your risk correctly.
    Invest conservatively so you can pay out claims when they come due.
    Don’t do anything else.
    Sit back and collect the spread. That’s it, folks.

    Seriously, that is it. Ask Warren Buffett, and he’ll probably tell you that if you follow those three rules, you’ll be fine. You won’t be the biggest or fastest grower, but you’ll be absolutely fine.

    The problems come when you get greedy and aren’t satisfied with the spread. And your greed can lead to certain actions that aren’t stated anywhere in the rules, including:

    Diversifying into fast-money proprietary trading.
    Leveraging your company 11-to-1.
    Neither of these is a goal of a well-run insurance company, yet AIG embraced both with open arms.

    Diworsifying
    But AIG self-destructed not because it screwed up in its insurance business. It didn’t fall into the trap of mispricing risk, as so many other insurers over the years have done. It also invested premiums fairly conservatively. So it followed Rules 1 and 2.

    Where it slipped up was in Rule 3. See, the folks at AIG thought they were so smart at insurance that they could start other capital-markets businesses … including proprietary asset management in things such as commodities, currencies, energy, interest rates, and the selling of default swaps on collateralized debt obligations (CDOs).

    This strategy worked beautifully — for a while. AIG created a separate business segment called Financial Services to trade in the aforementioned assets. This business had $204 billion in assets at year-end 2007, up from $60 billion in 1998.

    Operating income surged from $900 million in 1998 to $4.4 billion in 2005. Some of the moves it made were brilliant, such as the purchase of ILFC, an aircraft-leasing business. But the other trading businesses were the Medusa that turned the whole company to stone.

    Let me make one thing clear: Proprietary trading isn’t bad, in and of itself. Warren Buffett engages in it. But just like atomic weapons in the wrong hands, proprietary trading can do a lot of damage. The problem is when you start to get aggressive and don’t heed proper risk — when you start to speculate instead of invest.

    And there’s one other critical ingredient for disaster.

    The “L” word
    As in “leverage,” the sharp knife in corporate seppuku dramas. Leverage is, by my estimation, the No. 1 reason why companies fail.

    And compared with its peers, AIG had one of the sharpest knives around. Here’s how its leverage (assets to equity) stacked up against other insurance operations as of December 2007:

    AIG: 11 to 1.
    Markel (NYSE: MKL): 4 to 1.
    Berkshire Hathaway (NYSE: BRK-B): 2 to 1.
    Montpelier Re (NYSE: MRH): 2 to 1.
    Travelers (NYSE: TRV): 4 to 1.
    White Mountains Insurance (NYSE: WTM): 4 to 1.
    Chubb (NYSE: CB): 4 to 1.
    I would love it if someone gave me a rational, believable explanation of why leveraging your equity 11-to-1 is a good thing for an insurer. The sole job of an insurance CEO is to ensure that his or her company stays in business; the CEO’s job has nothing — absolutely nothing — to do with growing profits every year in a steady, smooth line.

    Surprises in insurance are almost always negative, so simply staying solvent is the overriding priority. A company can do just that by following the Three Rules.

    Two years ago, a few of my Fool colleagues had an interesting conversation with Chris Harris, the chief investment officer at reinsurer Montpelier Re. Harris noted that Montpelier invested its float primarily in U.S. Treasuries, Fannie and Freddie bonds (back when they were considered safe), and the like.

    When asked why he didn’t invest more aggressively, Harris said the company believed that it got all the risk it could handle on the other side of the fence, insuring against megacatastrophes.

    Even if you disagree, as an investor you have to recognize the judiciousness in this way of managing one’s business. An insurer that has to pay big claims from hurricanes Ike and Gustav and Typhoon Sinlaku — and additionally worry about the rapid decline in its investment portfolio as a result of the higher level of risks it has taken on — has a big problem.

    That insurer, folks, is AIG. And that big problem is now yours and mine.

    This really is bigger than Enron
    The edifice Hank Greenberg built has all come crashing down. Apparently, AIG didn’t realize that almost 40 years of 15% growth multiplied by a big fat zero equals just that: zero. It didn’t consider that its leverage left it exposed to a liquidity crisis, and it didn’t consider that its non-insurance businesses could bring down the whole company.

    In all fairness, management did not realize how much exposure it had to CDOs backed by subprime loans. This may or may not be true, but Buffett has famously stated that each one of these prospectuses has something like 15,000 pages, so it’s unlikely they were gone through in any great detail.

    But investing in things you don’t know is a huge risk, right? And that risk was compounded by having so much leverage. The fact is, the more leverage you have, the more careful you must be with the investments you hold, because your own capital structure is that much riskier.

    AIG did nothing of the sort. And so even though it has a rock-solid, wonderful insurance franchise, its greed and lack of care in its investing decisions took down one of the world’s great companies.

    What a shame. What a shame for all of the investors who lost billions thinking that this company was conservative. What a shame for taxpayers like you and me. What a shame for the United States’ reputation as a beacon of financial stability and conservatism.

    For Fool.com’s continuing coverage of this week’s events, check out “The Biggest Financial Story of the Past 50 Years.”

    Andrew Sullivan has no financial interest in any of the companies mentioned. Montpelier Re is a Motley Fool Hidden Gems selection. Markel and Berkshire Hathaway are Motley Fool Inside Value recommendations. Montpelier Re and Berkshire Hathaway are Motley Fool Stock Advisor picks. The Motley Fool owns shares of Berkshire Hathaway and has a disclosure policy.

    Share