Growing Your Own Replacement Parts

 

This is simply incredible. Watch the video about Claudia Castillo growing a replacement to part of her windpipe with her own stem cells. She didn’t grow the complete tube, but nevertheless…

Ms Castillo, who was born in Colombia, had suffered a tuberculosis infection that ravaged her airways, leaving her unable to do simple domestic tasks. Disease had caused her windpipe, or trachea, to collapse just at the point where it entered her lung. Without the pioneering operation in June, the lung would have been removed. Today she again has a normal life and is able to look after her two children. She can walk up stairs without getting breathless and has even been dancing.

Oh, my. Can you believe this? What the future holds for all the folks with damaged parts…

And does this mean as we age, we’ll be able to swap out the old for new? How will that affect aging? This is simply incredible.

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    Iron Man, Military Insect Spies

    Iron Man was wonderful, every bit of what the trailers promised–adventure, humor, and a huge dose of gosh-wow. Of course, the idea of military exoskeletons are not new. It’s been in science fiction for a long time. More recently, Dan Brown used the idea in his thriller Act of War. In fact, if you think about it, it becomes clear that airplanes, ships, and tanks are all exoskeletons. So this is all old hat. But when did we ever need a brand-spanking new idea to have a wonderful and new story? What’s important is what the do with the idea–the characters, problem, plot, and setting. And Iron Man does a wonderful job of imagining new twists on all these parts of story.

    *

    In other news, it appears the future is not so far away. The military is going to be using robot bugs for recon.

    British defence giant BAE Systems is creating a series of tiny electronic spiders, insects and snakes that could become the eyes and ears of soldiers on the battlefield, helping to save thousands of lives.

    Prototypes could be on the front line by the end of the year, scuttling into potential danger areas such as booby-trapped buildings or enemy hideouts to relay images back to troops safely positioned nearby.

    Soldiers will carry the robots into combat and use a small tracked vehicle to transport them closer to their targets.

    Then they would swarm into the building and relay images back to the soldiers’ hand-held or wrist-mounted computers, warning them of any threats inside.

    I’m all for saving lives and projecting power while we’re doing it. And robo spies are just cool. Except, of course, when they’re used against you…

    Humm, zing!

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  • Up & Over It does “We Speak No Americano”

    Because today is a special and you deserve to smile.

    Performed and choreographed by Suzanne Cleary & Peter Harding
    Film by: Jonny Reed
    Music: “We Speak No Americano” by Yolanda Be Cool & DCUP
    Up & Over It: http://www.facebook.com/upandoverit or http://www.upandoverit.com
    Produced by: http://puckproductions.com

    It appears “We Speak No Americano” by Yolanda Be Cool & DCUP samples the 1956 song “Tu vuò fà l’americano” (You pretend to be American), a Neapolitan language song by Italian singer Renato Carosone.

    If someone with some language skillz can translate, please do so in the comments.

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  • AIG bailout, risk, and writing

    With the current financial “crisis” I kept wondering what went wrong. Read this article on the AIG mess from the guys at the Motley Fool. That explaination of the AIG mess is very interesting. The other part of this current financial mess, the loaning-of-money-to-people-who-were-idiotic-credit-risks and the making-me-foot-the-bill-for-someone-else’s-assumption-of-ridiculous-risk, those two parts torque me.

    So why am I posting this in the Zing and Writers categories?

    Because it IS zing to me. You could write a high-finance thriller about this. You could write about a character who leveraged himself silly and is about to lose it all–in a smaller sense. You could write, hey, wait a minute. I just read a book about something similar–THE CHAIRMAN by Stephen Frey. It’s a 2.5/5 star book. Good enough that I had to finish it. Although not good enough to make my recommendation list. 

    The point is that stories are about problems and conflicts. And this understanding of the insurance industry provides some fertile ideas for both problems and conflicts.

    And since I can’t get the blasted link to work, here’s the full deal.

    AIG’s Failure Is So Much Bigger Than Enron
    By Andrew Sullivan, CFA
    September 17, 2008 Comment (54) Recommend (124)
    Enron — reviled, fraudulent Enron — destroyed more than $60 billion of shareholder value.

    AIG (NYSE: AIG), which the government just took over, has destroyed $180 billion already — and it almost brought down our entire financial system.

    We don’t know money
    Which is ironic, given AIG’s old television commercials, in which the giant letters “A I G” displayed on the screen while text flashed underneath that culminated in the following phrase — all in capital letters:

    WE KNOW MONEY

    There were no smiling couples, young children at play, or lounging retirees. No, AIG was above that — it was better than that.

    But here’s a news flash, AIG: You don’t know money.

    If you did, you’d have realized a few things. Insurance is terribly simple, as long as you follow the Three Rules:

    Price your risk correctly.
    Invest conservatively so you can pay out claims when they come due.
    Don’t do anything else.
    Sit back and collect the spread. That’s it, folks.

    Seriously, that is it. Ask Warren Buffett, and he’ll probably tell you that if you follow those three rules, you’ll be fine. You won’t be the biggest or fastest grower, but you’ll be absolutely fine.

    The problems come when you get greedy and aren’t satisfied with the spread. And your greed can lead to certain actions that aren’t stated anywhere in the rules, including:

    Diversifying into fast-money proprietary trading.
    Leveraging your company 11-to-1.
    Neither of these is a goal of a well-run insurance company, yet AIG embraced both with open arms.

    Diworsifying
    But AIG self-destructed not because it screwed up in its insurance business. It didn’t fall into the trap of mispricing risk, as so many other insurers over the years have done. It also invested premiums fairly conservatively. So it followed Rules 1 and 2.

    Where it slipped up was in Rule 3. See, the folks at AIG thought they were so smart at insurance that they could start other capital-markets businesses … including proprietary asset management in things such as commodities, currencies, energy, interest rates, and the selling of default swaps on collateralized debt obligations (CDOs).

    This strategy worked beautifully — for a while. AIG created a separate business segment called Financial Services to trade in the aforementioned assets. This business had $204 billion in assets at year-end 2007, up from $60 billion in 1998.

    Operating income surged from $900 million in 1998 to $4.4 billion in 2005. Some of the moves it made were brilliant, such as the purchase of ILFC, an aircraft-leasing business. But the other trading businesses were the Medusa that turned the whole company to stone.

    Let me make one thing clear: Proprietary trading isn’t bad, in and of itself. Warren Buffett engages in it. But just like atomic weapons in the wrong hands, proprietary trading can do a lot of damage. The problem is when you start to get aggressive and don’t heed proper risk — when you start to speculate instead of invest.

    And there’s one other critical ingredient for disaster.

    The “L” word
    As in “leverage,” the sharp knife in corporate seppuku dramas. Leverage is, by my estimation, the No. 1 reason why companies fail.

    And compared with its peers, AIG had one of the sharpest knives around. Here’s how its leverage (assets to equity) stacked up against other insurance operations as of December 2007:

    AIG: 11 to 1.
    Markel (NYSE: MKL): 4 to 1.
    Berkshire Hathaway (NYSE: BRK-B): 2 to 1.
    Montpelier Re (NYSE: MRH): 2 to 1.
    Travelers (NYSE: TRV): 4 to 1.
    White Mountains Insurance (NYSE: WTM): 4 to 1.
    Chubb (NYSE: CB): 4 to 1.
    I would love it if someone gave me a rational, believable explanation of why leveraging your equity 11-to-1 is a good thing for an insurer. The sole job of an insurance CEO is to ensure that his or her company stays in business; the CEO’s job has nothing — absolutely nothing — to do with growing profits every year in a steady, smooth line.

    Surprises in insurance are almost always negative, so simply staying solvent is the overriding priority. A company can do just that by following the Three Rules.

    Two years ago, a few of my Fool colleagues had an interesting conversation with Chris Harris, the chief investment officer at reinsurer Montpelier Re. Harris noted that Montpelier invested its float primarily in U.S. Treasuries, Fannie and Freddie bonds (back when they were considered safe), and the like.

    When asked why he didn’t invest more aggressively, Harris said the company believed that it got all the risk it could handle on the other side of the fence, insuring against megacatastrophes.

    Even if you disagree, as an investor you have to recognize the judiciousness in this way of managing one’s business. An insurer that has to pay big claims from hurricanes Ike and Gustav and Typhoon Sinlaku — and additionally worry about the rapid decline in its investment portfolio as a result of the higher level of risks it has taken on — has a big problem.

    That insurer, folks, is AIG. And that big problem is now yours and mine.

    This really is bigger than Enron
    The edifice Hank Greenberg built has all come crashing down. Apparently, AIG didn’t realize that almost 40 years of 15% growth multiplied by a big fat zero equals just that: zero. It didn’t consider that its leverage left it exposed to a liquidity crisis, and it didn’t consider that its non-insurance businesses could bring down the whole company.

    In all fairness, management did not realize how much exposure it had to CDOs backed by subprime loans. This may or may not be true, but Buffett has famously stated that each one of these prospectuses has something like 15,000 pages, so it’s unlikely they were gone through in any great detail.

    But investing in things you don’t know is a huge risk, right? And that risk was compounded by having so much leverage. The fact is, the more leverage you have, the more careful you must be with the investments you hold, because your own capital structure is that much riskier.

    AIG did nothing of the sort. And so even though it has a rock-solid, wonderful insurance franchise, its greed and lack of care in its investing decisions took down one of the world’s great companies.

    What a shame. What a shame for all of the investors who lost billions thinking that this company was conservative. What a shame for taxpayers like you and me. What a shame for the United States’ reputation as a beacon of financial stability and conservatism.

    For Fool.com’s continuing coverage of this week’s events, check out “The Biggest Financial Story of the Past 50 Years.”

    Andrew Sullivan has no financial interest in any of the companies mentioned. Montpelier Re is a Motley Fool Hidden Gems selection. Markel and Berkshire Hathaway are Motley Fool Inside Value recommendations. Montpelier Re and Berkshire Hathaway are Motley Fool Stock Advisor picks. The Motley Fool owns shares of Berkshire Hathaway and has a disclosure policy.

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  • Hitler’s Father and Snake Venom

    Hitler

    I’ve just begun HITLER by Ian Kershaw. Fascinating. And full of zing. Did you know that Hitler’s father:

    • Smoked like a chimney
    • Went to beer table after work instead of home
    • Took little interest in family and had multiple affairs with women
    • Beat Adolf almost daily, his gentle mother sometimes waiting outside the door while he thrashed his son
    • Had a passion for bee-keeping

    See, it’s weird, unexpected, almost against-type details like the last one that always seem to stimulate the zing meters.

    3 ways that snakes kill

    Let’s see: digest you, hundreds of blood clots, and brain attacks. Cool visuals of how the 3 types of venom work!

    And article explaining more about venom and why, for instance, sea snakes have such quick killing venom or why cobras have venom that could kill an elephant with one bite.

    So after reading this, I’m thinking of Vonda McIntyre’s Dreamsnake where in the future this woman uses snakes to manufacture medicine. Not in a factory, but in the snakes themselves. And she delivers them through natures brilliantly evolved hypodermics.

    But what other applications are there of this to a story? Heck, a murder mystery where you’d need to know the type of venom and the snakes nearby, a new type of dragon’s breath (instead of fire, could they breathe out a fog of one of the three toxins?), some new enzyme protein cocktail that leads to…superhero skills or is it immortality?

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    Black Chokecherry Syrup

    When you live where we do, you cannot hope to landscape likes folks in a warm suburb. First of all, at 6,000 feet with a min temp of -30 Fahrenheit you can’t grow a lot of warmer climate plants. Second, the deer seem to eat everything else you do grow. So we’ve been looking and I think I’ve found a tree to add.

    I actually found it earlier when I was biking around the beautiful Round Valley and had to stop and go back to revel in the delicious fragrance. But I didn’t know what it was at the time. I do now. 

    It’s the black chokecherry.

    It grows naturally up here. Has beautiful fragrant blossoms in the spring. And it produces fruit that can be made into a delicious syrup. Oh, the raccoons like it as well.

    Now when you eat the raw berry, unless you eat it late in the fall, you’re in for an astringent, alum after-punch. But we picked the berries up a canyon behind our town after the first frosts. In fact, many of our berries were wrinkled. They just fine raw. Even Lilia, my pickiest eater, enjoyed them.

    We picked about 1.25 gallon ice cream buckets of the stuff. Then we followed this recepie and made about 4 quarts of syrup.

    • 3 cups chokecherry juice (see first step)
    • 3 cups apple juice (not from a store, but cooked from apples)
    • 6 1/2 cups sugar
    • (I’ve heard some folks add 1/4 teaspoon almond extract for a stronger cherry taste)
    1. Wash chokecherries, place in a large kettle, barely cover with water and cook, covered, for about 30 minutes till the cherries are soft. Mash gently and strain the chokecherry juice through a sieve or cheesecloth.
    2. Do the same with the apples.
    3. Pour the juice into a large kettle; stir in the sugar.
    4. Cook on high, stirring constantly.
    5. Boil hard for 1 minute.
    6. Remove from heat and skim foam.
    7. To can: Pour hot syrup into sterilized hot jars to within 1/8th inch from top.

    It’s absolutely delicious on pancakes. 

     

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